2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glycolate Oxidase

Glycolate Oxidase

Glycolate oxidase (GO) is defined as a key enzyme in oxalate synthesis. Glycolate oxidasethat uses FMN to oxidize glycolate to glyoxalate, which is then aminated to form glycine, a normal amino acid.

Glycolate Oxidase Related Products (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-132588
    Lumasiran
    		Inhibitor
    Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1).
    Lumasiran
  • HY-132613
    Lumasiran sodium
    		Inhibitor 99.21%
    Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .
    Lumasiran sodium